Structured Treatment Interruption
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چکیده
4 In the context of this discussion, a subtle distinction is made between structured treatment interruption (STI) and structured intermittent treatment (SIT). STI has generally referred to 1 or more periods of interruption of potent antiretroviral therapy after a period of full viral suppression, with the principal goal being stimulation of HIV-1-specific immune responses that might subsequently improve control of viral replication in the absence of therapy. SIT has generally been applied to a treatment strategy of cyclic periods of potent antiretroviral therapy coupled with defined periods of no therapy, with the principal goal being maintenance of immune function and viral suppression with a reduction in overall drug exposure that might subsequently limit adverse effects or toxicities. However, in several of the studies addressed below this distinction is blurred.
منابع مشابه
Structured Treatment Interruptions
© 2001 Project Inform, Inc., 205 13th Street #2001, San Francisco, CA 94103-2461 Structured Treatment Interruption Workshop reprinted from PI Perspective #28, September 1999 The Foundation for AIDS and Immune Research (FAIR), in partnership with Project Inform and Treatment Action Group (TAG), co-sponsored a workshop in Boston at the end of July on structured therapy interruptions. Researchers ...
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